As of the census of 2000, there were 54,260 people, 15,018 households, and 11,804 families residing in the city.
As of 2007, 19.5% of National City residents have incomes listed below the poverty level, a figure above the 12.4% California state average. In 2000, the estimated household income was $29,826. Currently, the estimated household income is $39,158, which is below the California state average of $59,958.
Although crime has dropped since the 1980s and 1990's, National City still has significant gang and drug activity, and perennially leads San Diego County in violent crime.
For example, the number of violent crimes recorded by the FBI in 2003 was 546. The number of homicides for that year was 9, a rate of 16.6 per 100,000 people and three times the national average of 5.5. The violent crime rate was 9.7 per 1,000 people. From 2003 to 2007, National City averaged 5.2 homicides a year or an average rate of 9.6 per 100,000 people.
In 2008, National City was homicide-free for the first time since 1963, though it still led San Diego County in violent crime with a rate of 6.1 per 1,000 people (County average was 3.9 per 1,000 for that year).