As of the 2000 census, and according to the Los Angeles Almanac there were 41,255 people and 15,668 households residing in Chatsworth. The racial makeup of the neighborhood was 70.99% White, 14.33% Asian, 0.14% Pacific Islander, 3.51% African American, 0.51% Native American, 6.11% from other races, and 4.41% from two or more races. 16.31% of the population were Hispanic of any race.
Median household income in 2000 was $63,817.
During the late 1800s, Chatsworth was a main thoroughfare for the figures of the American West. Joaquin Murrieta and his bandits hid out in the rocky crevices around Stony Point. In 1861, a stagecoach trail, now called the Old Stagecoach Trail, was established through Chatsworth. It followed the old El Camino del Santa Susana y Simi trail over the Santa Susana Pass. That stagecoach route was used until about 1877. As late as 1891, another stage line still used the pass to provide a link between the city of San Fernando and Simi Valley. It is now a popular hiking trail in the Santa Susana Hills.citches
The Chatsworth train station is on the Coast Line of the Union Pacific Railroad. The Coast Line is shared with the Ventura County Line of Metrolink and Amtrak's Pacific Surfliner; the 2008 Chatsworth train collision occurred on the line.