Altamont is served by Interstate 70, U.S. Route 40, and Illinois Route 128, all of which pass through its city limits. What is now U.S. Route 40 was once known as the "National Road" and before that the "Cumberland Road".
Amtrak service to Chicago and New Orleans and all points in between can be accessed in Effingham, 12 miles (19 km) to the east.