As of the census of 2000, there were 27,619 people, 10,275 households, and 7,778 families residing in the county. The population density was 71 people per square mile (27/km²). There were 10,749 housing units at an average density of 28 per square mile (11/km²). The racial makeup of the county was 98.77% White, 0.05% Black or African American, 0.19% Native American, 0.31% Asian, 0.18% from other races, and 0.50% from two or more races. 0.74% of the population were Hispanic or Latino of any race. 57.1% were of German, 8.5% Irish, 7.4% American and 5.8% English ancestry according to Census 2000.
There were 10,275 households out of which 37.70% had children under the age of 18 living with them, 65.30% were married couples living together, 7.30% had a female householder with no husband present, and 24.30% were non-families. 21.30% of all households were made up of individuals and 9.60% had someone living alone who was 65 years of age or older. The average household size was 2.65 and the average family size was 3.09.
In the county the population was spread out with 26.40% under the age of 18, 7.40% from 18 to 24, 30.60% from 25 to 44, 22.20% from 45 to 64, and 13.40% who were 65 years of age or older. The median age was 38 years. For every 100 females there were 96.80 males. For every 100 females age 18 and over, there were 93.60 males.
The median income for a household in the county was $55,320, and the median income for a family was $62,397. Males had a median income of $41,243 versus $27,130 for females. The per capita income for the county was $22,954. About 2.30% of families and 3.40% of the population were below the poverty line, including 2.80% of those under age 18 and 7.30% of those age 65 or over.
The closest access to and bridges over the Kaskaskia are downriver at Baldwin in Randolph County and upriver at New Athens in St. Clair County. South of Monroe County, there is a ferry across the Mississippi in Randolph County, providing access to Ste. Genevieve, Missouri and Pere Marquette State Park, and a bridge at Chester.
While the railroad played a large part in the history and development of the county, the main line through the county, running along Illinois Route 3, has been abandoned and removed. However, Union Pacific tracks run though the Bottoms from the intermodal yard at Dupo in St. Clair County, running roughly parallel to Bluff Rd. which crosses them several times, through old Valmeyer and Fults on past Prairie du Rocher in Randolph County. The tracks are still in use, but carry only freight, and have no stops in Monroe County.
There is a small airfield in the Bottoms west of Columbia called Sackman Field.