As of a census estimate in 2006, there were 16,651 people, 7,077 households, and 4,295 families residing in the city. The population density was 1,438.9 people per square mile (555.7/km²). There were 7,871 housing units at an average density of 680.2/sq mi (262.7/km²).
The racial makeup of the city was 88.6% White, 9.9% African American, 0.6% Native American, 0.5% Asian, 0.48% from other races, and 0.5% from two or more races. Hispanic or Latino of any race were 1.4% of the population. According to a 2008 demographical study conducted by Claritas, Inc., there are an estimated 26,777 people who live within a five-mile radius of Poplar Bluff’s City Center.
There were 7,870 households out of which 52.7% were married couples living together, 20.28% had a female householder with no husband present, and 39.3% were non-families. 34.9% of all households were made up of individuals and 17.0% had someone living alone who was 65 years of age or older. The average household size was 2.27 and the average family size was 2.9.
In the city the population was spread out with 24.3% under the age of 18, 8.8% from 18 to 24, 25.5% from 25 to 44, 21.5% from 45 to 64, and 19.9% who were 65 years of age or older. The median age was 38.7 years. For every 100 females there were 83.6 males. For every 100 females age 18 and over, there were 78.5 males.
The median income for a household in the city was $22,068, and the median income for a family was $28,744. The per capita income for the city was $13,996. About 19.3% of families and 24.4% of the population were below the poverty line, including 34.4% of those under age 18 and 17.6% of those age 65 or over.