Cape Girardeau County is the central hub of the Cape Girardeau–Jackson, MO-IL Metropolitan Statistical Area.
As of the census of 2000, there were 68,693 people, 26,980 households, and 17,941 families residing in the county. The population density was 119 people per square mile (46/km²). There were 29,434 housing units at an average density of 51 per square mile (20/km²). The racial makeup of the county was 92.13% White, 5.28% Black or African American, 0.36% Native American, 0.75% Asian, 0.03% Pacific Islander, 0.31% from other races, and 1.15% from two or more races. Approximately 0.91% of the population were Hispanic or Latino of any race.
There were 26,980 households out of which 31.20% had children under the age of 18 living with them, 53.80% were married couples living together, 9.80% had a female householder with no husband present, and 33.50% were non-families. 27.30% of all households were made up of individuals and 10.10% had someone living alone who was 65 years of age or older. The average household size was 2.42 and the average family size was 2.96.
In the county the population was spread out with 23.40% under the age of 18, 13.40% from 18 to 24, 27.80% from 25 to 44, 21.60% from 45 to 64, and 13.80% who were 65 years of age or older. The median age was 35 years. For every 100 females there were 93.20 males. For every 100 females age 18 and over, there were 90.00 males.
The median income for a household in the county was $45,862, and the median income for a family was $58,037. Males had a median income of $32,371 versus $20,833 for females. The per capita income for the county was $24,303. About 6.70% of families and 11.10% of the population were below the poverty line, including 11.40% of those under age 18 and 10.10% of those age 65 or over.