The Cape Girardeau-Jackson, MO-IL Metropolitan Statistical Area embraces Alexander County, Illinois, Bollinger County, Missouri and Cape Girardeau County, Missouri.
As of the census of 2000, there were 35,349 people, 14,380 households, and 8,297 families residing in the city. The population density was 1,456.5 people per square mile (562.4/km²). There were 15,827 housing units at an average density of 652.1/sq mi (251.8/km²). The racial makeup of the city was 87.32% White, 9.30% Black or African American, 1.13% Asian, 0.39% Native American, 0.04% Pacific Islander, 0.43% from other races, and 1.40% from two or more races. Hispanic or Latino of any race were 1.10% of the population.
There were 14,380 households out of which 25.7% had children under the age of 18 living with them, 43.8% were married couples living together, 10.9% had a female householder with no husband present, and 42.3% were non-families. 33.6% of all households were made up of individuals and 11.5% had someone living alone who was 65 years of age or older. The average household size was 2.24 and the average family size was 2.90.
The age distribution is 20.5% under the age of 18, 18.4% from 18 to 24, 25.6% from 25 to 44, 19.9% from 45 to 64, and 15.5% who were 65 years of age or older. The median age was 34 years. For every 100 females there were 89.5 males. For every 100 females age 18 and over, there were 86.9 males.
The median income for a household in the city was $36,502, and the median income for a family was $47,592. Males had a median income of $31,575 versus $21,392 for females. The per capita income for the city was $21,877. About 8.5% of families and 15.2% of the population were below the poverty line, including 16.5% of those under age 18 and 8.6% of those age 65 or over.
Four of the largest employers in Cape Girardeau are Southeast Missouri Hospital, Saint Francis Medical Center, Procter and Gamble, and Southeast Missouri State University.
Cape Girardeau Regional Airport serves the city. Cape Girardeau is also served by Interstate 55 and an Interstate business loop, known locally as "Kingshighway." Cape Girardeau County Transit Authority provides public transportation of the city with buses and taxis. The shuttle system operates out of Southeast Missouri State University to transport college students who do not have a vehicle to various destinations in the city.