As of the census of 2000, there are 185,776 people, with a total urban population of 299,290, 76,247 households, and 46,205 families residing in the city. The population density is 1,706.7 people per square mile (659.0/km²). There are 82,593 housing units at an average density of 758.8/sq mi (293.0/km²). The racial makeup of the city is 55.57% White, 37.10% African American, 0.31% Native American, 1.13% Asian, 0.04% Pacific Islander, 4.29% from other races, and 1.56% from two or more races. 8.64% of the population are Hispanic or Latino of any race.
There are 76,247 households out of which 28.0% have children under the age of 18 living with them, 40.2% are married couples living together, 16.6% have a female householder with no husband present, and 39.4% are non-families. 33.4% of all households are made up of individuals and 10.7% have someone living alone who is 65 years of age or older. The average household size is 2.32 and the average family size is 2.95.
In the city the population is spread out with 23.3% under the age of 18, 11.7% from 18 to 24, 30.4% from 25 to 44, 20.9% from 45 to 64, and 13.7% who are 65 years of age or older. The median age is 35 years. For every 100 females there are 88.7 males. For every 100 females age 18 and over, there are 84.2 males.
The median income for a household in the city is $39,589, and the median income for a family is $46,595. Males have a median income of $32,398 versus $25,335 for females. The per capita income for the city is $39,468. 11.2% of the population and 4.3% of families are below the poverty line. Out of the total population, 8.3% of those under the age of 18 and 7.1% of those 65 and older are living below the poverty line.
A 2006 cost of living survey (Mercer) ranked Winston-Salem as the 124th most most expensive city in the U.S. or Europe, - slightly half as expensive as living in Moscow.
US 52 (with runs concurrent with NC 8) is the predominant north-south freeway through Winston-Salem; it passes through the heart of downtown. Business 40 is the main east-west freeway through downtown Winston-Salem, but further south, a bypass loop (built in 1993) of I-40 links many of the area's shopping districts. US 311, also a freeway, links Winston-Salem to High Point (southeast) and follows I-40 and US 52 through the Winston-Salem business district. US 421, which shares Business 40 through downtown, splits in the western part of the city onto its own freeway west (signed north) toward Wilkesboro, North Carolina and Boone, North Carolina.
The Winston Salem Northern Beltway is a proposed freeway that will loop around the city to the north, providing a route for the Future I-74 on the eastern section and the Future Auxiliary Route I-274 on the western section. The NCDOT plans for this project to begin after 2010.
By 2011, US 52 south of I-40 will be signed as Spur Route I-285. The Winston-Salem Department of Transportation also plans for the US 311 freeway to be extended north along the east side of the city to Business I-40 by 2030, according to the Long Range Plan.
Other major thoroughfares in Winston-Salem include NC 67 (Silas Creek Parkway & Reynolda Road), NC 150 (Peters Creek Parkway), US 158 (Stratford Road), University Parkway, Martin Luther King Jr. Boulevard, North Point Boulevard, and Hanes Mall Boulevard.
Winston-Salem is served by Greensboro's Piedmont Triad International Airport. The airport also serves much of the surrounding Piedmont Triad area, including High Point, North Carolina.
A smaller airport, known as Smith Reynolds Airport, is located within the city limits, just northeast of downtown. It is mainly used for general aviation and charter flights. Every year, Smith Reynolds Airport hosts an air show for the general public. The Smith Reynolds Airport is home to the Winston-Salem Composite Squadron, Civil Air Patrol.
Amtrak runs a thruway motorcoach, twice daily in each direction, between Winston-Salem and the Amtrak station in nearby High Point. Buses depart from the Winston-Salem Transportation Center, then stop on the university campus before traveling to High Point. From the High Point station, riders can board the Crescent line or the Carolinian or Piedmont lines. These lines run directly to local North Carolina destinations as well as cities across the Southeast, as far west as New Orleans and as far north as New York City. Chicago is also accessible by transferring in Washington, D.C.