Andrews was incorporated on February 2, 1937. Both the city and county were named for Richard Andrews, the first Texan soldier to die in the Texas Revolution.
United States Highway 385 (north-south) and Texas State Highway 115 (east-west) intersect through Andrews.
As of the census of 2000, there were 9,652 people, 3,478 households, and 2,598 families residing in the city. The population density was 2,017.5 people per square mile (779.6/km²). There were 4,047 housing units at an average density of 845.9/sq mi (326.9/km²). The racial makeup of the city was 75.65% White, 2.04% African American, 0.90% Native American, 0.71% Asian, 0.03% Pacific Islander, 17.72% from other races, and 2.94% from two or more races. Hispanic or Latino of any race were 41.95% of the population.
There were 3,478 households out of which 40.3% had children under the age of 18 living with them, 61.3% were married couples living together, 10.2% had a female householder with no husband present, and 25.3% were non-families. 23.7% of all households were made up of individuals and 11.1% had someone living alone who was 65 years of age or older. The average household size was 2.75 and the average family size was 3.26.
In the city the population was spread out with 31.5% under the age of 18, 8.1% from 18 to 24, 27.3% from 25 to 44, 20.0% from 45 to 64, and 13.1% who were 65 years of age or older. The median age was 34 years. For every 100 females there were 93.9 males. For every 100 females age 18 and over, there were 88.6 males.
The median income for a household in the city was $32,774, and the median income for a family was $36,172. Males had a median income of $31,527 versus $22,266 for females. The per capita income for the city was $16,101. About 15.3% of families and 17.7% of the population were below the poverty line, including 22.5% of those under age 18 and 12.8% of those age 65 or over.
Andrews is the only populated city in Andrews County.