Wayne County is a part of the Huntington-Ashland, WV-KY-OH, Metropolitan Statistical Area (MSA). As of the 2000 census, the MSA had a population of 288,649.
As of the census of 2000, there were 42,903 people, 17,239 households, and 12,653 families residing in the county. The population density was 85 people per square mile (33/km²). There were 19,107 housing units at an average density of 38 per square mile (15/km²). The racial makeup of the county was 98.79% White, 0.13% Black or African American, 0.23% Native Americans, 0.20% Asian, 0.02% Pacific Islander, 0.08% from other races, and 0.56% from two or more races. 0.47% of the population were Hispanic or Latino of any race.
There were 17,239 households out of which 31.20% had children under the age of 18 living with them, 59.20% were married couples living together, 10.80% had a female householder with no husband present, and 26.60% were non-families. 24.10% of all households were made up of individuals and 11.10% had someone living alone who was 65 years of age or older. The average household size was 2.48 and the average family size was 2.92.
In the county, the population was spread out with 23.40% under the age of 18, 8.70% from 18 to 24, 27.70% from 25 to 44, 25.30% from 45 to 64, and 14.90% who were 65 years of age or older. The median age was 38 years. For every 100 females there were 95.80 males. For every 100 females age 18 and over, there were 91.80 males.
The median income for a household in the county was $27,352, and the median income for a family was $32,458. Males had a median income of $31,554 versus $20,720 for females. The per capita income for the county was $14,906. About 16.20% of families and 19.60% of the population were below the poverty line, including 25.50% of those under age 18 and 15.20% of those age 65 or over.