Often called Wisconsin's second oldest city, Prairie du Chien was established by French voyageurs in the late 17th century. The city is located near the confluence of the Wisconsin River and the Mississippi River, a strategic point along the Fox-Wisconsin Waterway that connects the Great Lakes with the Mississippi.
Early French visitors to the site found it occupied by a group of Fox Indians led by a chief whose name, Alim, meant "Chien" in French, or "Dog" in English. As a result, the French explorers named the location "Prairie du Chien", which is French for "Land of Dog". Originally this name applied only to the plain upon which the settlement is located, but it was later extended to mean the city as well. The city of Prairie du Chien is located between the Town of Prairie du Chien and the Town of Bridgeport. Though the origin of the name is French, it is pronounced as in English, "prairie doo sheen".
As of the census of 2000, there were 6,018 people, 2,376 households, and 1,473 families residing in the city. The population density was 1,075.9 people per square mile (415.7/km²). There were 2,564 housing units at an average density of 458.4/sq mi (177.1/km²). The racial makeup of the city was 95.06% White, 3.61% Black or African American, 0.28% Native American, 0.17% Asian, 0.02% Pacific Islander, 0.08% from other races, and 0.78% from two or more races. 0.88% of the population were Hispanic or Latino of any race.
There were 2,376 households out of which 29.3% had children under the age of 18 living with them, 48.7% were married couples living together, 10.2% had a female householder with no husband present, and 38.0% were non-families. 33.0% of all households were made up of individuals and 17.1% had someone living alone who was 65 years of age or older. The average household size was 2.28 and the average family size was 2.92.
In the city the population was spread out with 24.2% under the age of 18, 11.4% from 18 to 24, 24.3% from 25 to 44, 21.8% from 45 to 64, and 18.3% who were 65 years of age or older. The median age was 38 years. For every 100 females there were 100.5 males. For every 100 females age 18 and over, there were 97.3 males.
The median income for a household in the city was $34,038, and the median income for a family was $43,444. Males had a median income of $29,595 versus $20,183 for females. The per capita income for the city was $17,680. About 6.4% of families and 8.1% of the population were below the poverty line, including 11.7% of those under age 18 and 4.8% of those age 65 or over.